Formal asymmetric biocatalytic reductive amination.
نویسندگان
چکیده
منابع مشابه
Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds
Amines constitute the major targets for the production of a plethora of chemical compounds that have applications in the pharmaceutical, agrochemical and bulk chemical industries. However, the asymmetric synthesis of α-chiral amines with elevated catalytic efficiency and atom economy is still a very challenging synthetic problem. Here, we investigated the biocatalytic reductive amination of car...
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Optically active amines are attracting increasing interest in the food, agrochemical, and pharmaceutical industries as building blocks for novel compounds and as templates for asymmetric synthesis. One of the most common methods for preparing amines is the reductive amination of carbonyl compounds. We have successfully explored the rhodiumcatalyzed asymmetric reductive amination with hydrogen a...
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 47 48 شماره
صفحات -
تاریخ انتشار 2008